Transfusion-transmitted infectious diseases

被引：126

作者：

Allain, Jean-Pierre ^{[1
]}

Stramer, Susan L. ^{[2
]}

Carneiro-Proietti, A. B. F. ^{[3
]}

Martins, M. L. ^{[3
]}

Lopes da Silva, S. N. ^{[3
]}

Ribeiro, M. ^{[3
]}

Proietti, F. A. ^{[3
]}

Reesink, Henk W. ^{[4
]}

机构：

[1] Univ Cambridge, Dept Haematol, Cambridge, England

[2] Amer Red Cross, Sci Support Off, Gaithersburg, MD USA

[3] Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil

[4] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, NL-1105 AZ Amsterdam, Netherlands

来源：

BIOLOGICALS | 2009年 / 37卷 / 02期

关键词：

Hepatitis; AIDS; West Nile virus; Dengue; Chagas disease; HEPATITIS-B-VIRUS; WEST-NILE-VIRUS; CREUTZFELDT-JAKOB-DISEASE; BLOOD-DONORS; UNITED-STATES; GENOTYPE-E; TRANSMISSION; EPIDEMIOLOGY; PREVENTION; MALARIA;

D O I：

10.1016/j.biologicals.2009.01.002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A spectrum of blood-borne infectious agents is transmitted through transfusion of infected blood donated by apparently healthy and asymptomatic blood donors. The diversity of infectious agents includes hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency viruses (HIV-1/2), human T-cell lymphotropic Viruses (HTLV-I/II), Cytomegalovirus (CMV), Parvovirus 1319, West Nile Virus (WNV), Dengue virus, trypanosomiasis, malaria, and variant CJD. Several strategies are implemented to reduce the risk of transmitting these infectious agents by donor exclusion for clinical history of risk factors, screening for the serological markers of infections, and nucleic acid testing (NAT) by viral gene amplification for direct and sensitive detection of the known infectious agents. Consequently, transfusions are safer now than ever before and we have learnt how to mitigate risks of emerging infectious diseases such as West Nile, Chikungunya, and Dengue viruses. (C) 2009 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.

引用

页码：71 / 77

页数：7

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