The power and the promise of oncogene-induced senescence markers

被引：320

作者：

Collado, Manuel ^{[1
]}

Serrano, Manuel ^{[1
]}

机构：

[1] Spanish Natl Canc Ctr, CNIO, Mol Oncol Program, Madrid, Spain

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 06期

关键词：

D O I：

10.1038/nrc1884

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, it has been shown that oncogene-induced senescence ( OIS) occurs during the early stages of tumorigenesis. Senescent tumour cells are abundant within premalignant neoplastic lesions, whereas they are scarce in malignant tumours. This association of senescence with the premalignant stages of tumour progression opens the possibility of using senescence markers as diagnostic and prognostic tools. Moreover, some chemotherapeutic protocols induce senescence in tumour cells and, consequently, senescence markers could help to monitor treatment response.

引用

页码：472 / 476

页数：5

共 51 条

[1] INVESTIGATION OF THE ROLE OF G(1)/S CELL-CYCLE MEDIATORS IN CELLULAR SENESCENCE
AFSHARI, CA
VOJTA, PJ
ANNAB, LA
FUTREAL, PA
WILLARD, TB
BARRETT, JC
[J]. EXPERIMENTAL CELL RESEARCH, 1993, 209 (02) : 231 - 237
[2] Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
Alcorta, DA
Xiong, Y
Phelps, D
Hannon, G
Beach, D
Barrett, JC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) : 13742 - 13747
[3] Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence
Barradas, M
Gonos, ES
Zebedee, Z
Kolettas, E
Petropoulou, C
Delgado, MD
León, J
Hara, E
Serrano, M
[J]. EXPERIMENTAL CELL RESEARCH, 2002, 273 (02) : 127 - 137
[4] Oncogene-induced senescence as an initial barrier in lymphoma development
Braig, M
Lee, S
Loddenkemper, C
Rudolph, C
Peters, AHFM
Schlegelberger, B
Stein, H
Dörken, B
Jenuwein, T
Schmitt, CA
[J]. NATURE, 2005, 436 (7051) : 660 - 665
[5] Lipofuscin: Mechanisms of age-related accumulation and influence on cell function
Brunk, UT
Terman, A
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 (05) : 611 - 619
[6] Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
Campisi, J
[J]. CELL, 2005, 120 (04) : 513 - 522
[7] Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent
Chang, BD
Swift, ME
Shen, M
Fang, J
Broude, EV
Roninson, IB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (01) : 389 - 394
[8] Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Chen, ZB
Trotman, LC
Shaffer, D
Lin, HK
Dotan, ZA
Niki, M
Koutcher, JA
Scher, HI
Ludwig, T
Gerald, W
Cordon-Cardo, C
Pandolfi, PP
[J]. NATURE, 2005, 436 (7051) : 725 - 730
[9] Tumour biology -: Senescence in premalignant tumours
Collado, M
Gil, J
Efeyan, A
Guerra, C
Schuhmacher, AJ
Barradas, M
Benguría, A
Zaballos, A
Flores, JM
Barbacid, M
Beach, D
Serrano, M
[J]. NATURE, 2005, 436 (7051) : 642 - 642
[10] Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland
Denchi, EL
Attwooll, C
Pasini, D
Helin, K
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (07) : 2660 - 2672

← 1 2 3 4 5 6 →