Molecular and Cellular Immune Responses to Ischemic Brain Injury

被引：101

作者：

Seifert, Hilary A. ^{[1
]}

Pennypacker, Keith R. ^{[1
]}

机构：

[1] Univ S Florida, Morsani Coll Med, Sch Basic Biomed Sci, Dept Mol Pharmacol & Physiol, Tampa, FL 33612 USA

来源：

TRANSLATIONAL STROKE RESEARCH | 2014年 / 5卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Spleen; Interferon gamma; Stroke; Tcells; TUMOR-NECROSIS-FACTOR; CEREBRAL-ARTERY OCCLUSION; REGULATORY T-CELLS; CORD BLOOD-CELLS; INTERFERON-GAMMA; EXPERIMENTAL STROKE; SPLEEN CONTRIBUTES; CONVERTING ENZYME; SPLENIC RESERVOIR; FACTOR-ALPHA;

D O I：

10.1007/s12975-014-0349-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Despite extensive research into stroke pathology, there have not been any major recent advancements in stroke therapeutics. Animal models of cerebral ischemia and clinical data have been used to investigate the progressive neural injury that occurs after an initial ischemic insult. This has lead researchers to focus more on the peripheral immune response that is generated as a result of cerebral ischemia. The therapies that have been developed as a result of this research thus far have proven ineffective in clinical trials. The failure of these therapeutics in clinical trials is thought to be due to the broad immunosuppression elicited as a result of the treatments and the cerebral ischemia itself. Emerging evidence indicates a more selective modulation of the immune system following stroke could be beneficial. The spleen has been shown to exacerbate neural injury following experimental stroke and would provide a strong therapeutic target. Selecting facets of the immune system to target would allow the protective and regenerative properties of the immune response to remain intact while blunting the pro-inflammatory response generated towards the injured brain.

引用

页码：543 / 553

页数：11

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