Continuous neurogenesis in the adult brain

被引：72

作者：

Imayoshi, Itaru ^{[1
,2
]}

Sakamoto, Masayuki ^{[1
,3
]}

Ohtsuka, Toshiyuki ^{[1
,2
]}

Kageyama, Ryoichiro ^{[1
,2
]}

机构：

[1] Kyoto Univ, Inst Virus Res, Kyoto 6068507, Japan

[2] CREST, Japan Sci & Technol Agcy, Kyoto 6068507, Japan

[3] Kyoto Univ, Grad Sch Biostudies, Kyoto 6068502, Japan

来源：

DEVELOPMENT GROWTH & DIFFERENTIATION | 2009年 / 51卷 / 03期

基金：

日本学术振兴会;

关键词：

adult neurogenesis; Cre; dentate gyrus; neural stem cell; olfactory bulb; NEURAL STEM-CELLS; GENERATED GRANULE CELLS; CENTRAL-NERVOUS-SYSTEM; MOUSE OLFACTORY-BULB; RAT DENTATE GYRUS; CRE RECOMBINASE ACTIVITY; HIPPOCAMPAL NEUROGENESIS; POSTNATAL NEUROGENESIS; SOMATIC MUTAGENESIS; MAMMALIAN BRAIN;

D O I：

10.1111/j.1440-169X.2009.01094.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neurogenesis occurs throughout adulthood in the mammalian brain by coordinated proliferation and differentiation of adult neural stem cells. Newborn neurons are incorporated into the functional networks of both the olfactory bulb and the hippocampal dentate gyrus, suggesting significant roles of adult neurogenesis in brain functions. In this review, we discuss the recent findings about the integration mode of new neurons into the existing neural circuits. We further address the potential significance of adult neurogenesis in higher brain functions such as olfactory and spatial memory.

引用

页码：379 / 386

页数：8

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