How do Rab proteins function in membrane traffic?

被引：59

作者：

Armstrong, J ^{[1
]}

机构：

[1] Univ Sussex, Sch Biol Sci, Brighton BN1 9QG, E Sussex, England

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2000年 / 32卷 / 03期

关键词：

secretion; endocytosis; vesicle traffic; GTP-binding protein;

D O I：

10.1016/S1357-2725(99)00112-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The Rabs are a group of GTP-binding proteins implicated for some time in the targeting of different transport vesicles within the cell, but it has been unclear how they function, or how they relate to a second group of targeting proteins, the SNAREs. Recent work, discussed in this review, has used biophysical, biochemical and genetic approaches to begin to answer these questions for Rab3, Rab5 and the yeast protein Sec4p. However, the results from these three Rabs lead to a surprising conclusion: the different Rabs seem to function via highly diverse target proteins. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：303 / 307

页数：5

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