Effects of SCH 58261, an adenosine A2A receptor antagonist, on quinpirole-induced turning in 6-hydroxydopamine-lesioned rats:: Lack of tolerance after chronic caffeine intake

被引：40

作者：

Popoli, P ^{[1
]}

Reggio, R ^{[1
]}

Pèzzola, A ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Pharmacol, I-00161 Rome, Italy

来源：

NEUROPSYCHOPHARMACOLOGY | 2000年 / 22卷 / 05期

关键词：

adenosine A(2A) receptors; dopamine D-1 and D-2 receptors; Parkinson's disease; chronic caffeine treatment;

D O I：

10.1016/S0893-133X(99)00144-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rats, a rodent model of Parkinson's disease (PD), the adenosine A(2A) receptor antagonist SCH 58261 significantly increased (+180%, p<.01) the number of rotations induced by a low dose of quinpirole (a dopamine D-2 receptor agonist), while it did not significantly modify the effects of a comparably low dose of SKF 38393 (a dopamine D-1 receptor agonist). The dose-dependent potentiating effects of SCH 58261 on quinpirole-induced turning were similar in caffeine-treated rats (1 g/l in drinking water over 14 days) and control animals (tap water). The selective potentiating effects of SCH 58261 on D-2-dependent turning confirm the existence of a potent and specific A(2A)/D-2 receptor-receptor interaction. The persistence of the potentiating effects of SCH 58261 after chronic caffeine intake suggests that no tolerance should develop towards the antiparkinsonian effects of adenosine A(2A) receptor antagonists with chronic treatment. (C) American College of Neuropsychopharmacology.

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页码：522 / 529

页数：8

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