Is Prehypertension Really Different from Normotension and Hypertension? A Case-Control Pilot Proteomic Study in Chinese

被引：14

作者：

Wang, Zuoguang ^{[1
]}

Peng, Xiaoyun ^{[2
]}

Tao, Yanduo ^{[2
]}

Liu, Ya ^{[1
]}

Liu, Jieling ^{[1
]}

Chen, Xingjun ^{[1
]}

Wen, Shaojun ^{[1
]}

Wu, Zhaosu ^{[3
]}

机构：

[1] Beijing Anzhen Hosp, Beijing Inst Heart Lung Blood Vessel Dis, Dept Hypertens, Beijing, Peoples R China

[2] Chinese Acad Sci, Inst WN Plateau Biol, Beijing 100864, Peoples R China

[3] Beijing Anzhen Hosp, Beijing Inst Heart Lung Blood Vessel Dis, Dept Cardiovasc Epidemiol, Beijing, Peoples R China

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2009年 / 31卷 / 04期

基金：

国家高技术研究发展计划(863计划);

关键词：

prehypertension; hypertension; proteomics; pathogenesis; plasma; NORMAL BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; PLASMA; ANGIOTENSIN; INFLAMMATION; PROTEIN; ASSOCIATION; WORLDWIDE; ALPHA;

D O I：

10.1080/10641960902977890

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

This study was designed to investigate the differences in the plasma proteome of healthy normotensive, prehypertensive, and hypertensive subjects. A case-control pilot study was conducted among well-matched subjects. Plasma protein was analyzed by two-dimensional electrophoresis combined with MALDI-TOF mass spectrometry. The results showed that there were 22 differentially expressed spots among the three groups, which corresponded to 18 proteins involved in inflammation and immunity, lipid metabolism, transport, coagulation and fibrinolysis, cell proliferation and apoptosis, and anti-oxidation. With an increase in blood pressure, these proteins were differentially expressed which indicated that prehypertension probably was an early stage of hypertension.

引用

页码：316 / 329

页数：14

共 44 条

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