The role of type I interferons in intestinal infection, homeostasis, and inflammation

被引：76

作者：

Cho, Hyeseon ^{[1
]}

Kelsall, Brian L. ^{[1
]}

机构：

[1] NIAID, Mucosal Immunobiol Sect, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

来源：

IMMUNOLOGICAL REVIEWS | 2014年 / 260卷 / 01期

基金：

美国国家卫生研究院;

关键词：

type I interferons; enteric microbial infection; intestinal inflammation; DOUBLE-STRANDED-RNA; PLASMACYTOID DENDRITIC CELLS; INNATE IMMUNE-RESPONSES; NATURAL-KILLER-CELLS; INDUCIBLE GENE-I; LISTERIA-MONOCYTOGENES; RIG-I; ULCERATIVE-COLITIS; IFN-BETA; ROTAVIRUS INFECTION;

D O I：

10.1111/imr.12195

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Type I interferons are a widely expressed family of effector cytokines that promote innate antiviral and antibacterial immunity. Paradoxically, they can also suppress immune responses by driving production of anti-inflammatory cytokines, and dysregulation of these cytokines can contribute to host-mediated immunopathology and disease progression. Recent studies describe their anti-inflammatory role in intestinal inflammation and the locus containing IFNAR, a heterodimeric receptor for the type I interferons has been identified as a susceptibility region for human inflammatory bowel disease. This review focuses on the role of type I IFNs in the intestine in health and disease and their emerging role as immune modulators. Clear understanding of type I IFN-mediated immune responses may provide avenues for fine-tuning existing IFN treatment for infection and intestinal inflammation.

引用

页码：145 / 167

页数：23

共 252 条

[1]

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids [J].

Abdullah, Zeinab ;

Schlee, Martin ;

Roth, Susanne ;

Abu Mraheil, Mobarak ;

Barchet, Winfried ;

Boettcher, Jan ;

Hain, Torsten ;

Geiger, Sergej ;

Hayakawa, Yoshihiro ;

Fritz, Joerg H. ;

Civril, Filiz ;

Hopfner, Karl-Peter ;

Kurts, Christian ;

Ruland, Juergen ;

Hartmann, Gunther ;

Chakraborty, Trinad ;

Knolle, Percy A. .

EMBO JOURNAL, 2012, 31 (21) :4153-4164

[2]

Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells [J].

Abe, Kazumichi ;

Nguyen, Kim Phung ;

Fine, Sean D. ;

Mo, Ji-Hun ;

Shen, Carol ;

Shenouda, Steve ;

Corr, Maripat ;

Jung, Steffen ;

Lee, Jongdae ;

Eckmann, Lars ;

Raz, Eyal .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (43) :17022-17027

[3]

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate [J].

Ablasser, Andrea ;

Bauernfeind, Franz ;

Hartmann, Gunther ;

Latz, Eicke ;

Fitzgerald, Katherine A. ;

Hornung, Veit .

NATURE IMMUNOLOGY, 2009, 10 (10) :1065-U40

[4]

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity [J].

Abt, Michael C. ;

Osborne, Lisa C. ;

Monticelli, Laurel A. ;

Doering, Travis A. ;

Alenghat, Theresa ;

Sonnenberg, Gregory F. ;

Paley, Michael A. ;

Antenus, Marcelo ;

Williams, Katie L. ;

Erikson, Jan ;

Wherry, E. John ;

Artis, David .

IMMUNITY, 2012, 37 (01) :158-170

[5]

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 [J].

Anderson, Carl A. ;

Boucher, Gabrielle ;

Lees, Charlie W. ;

Franke, Andre ;

D'Amato, Mauro ;

Taylor, Kent D. ;

Lee, James C. ;

Goyette, Philippe ;

Imielinski, Marcin ;

Latiano, Anna ;

Lagace, Caroline ;

Scott, Regan ;

Amininejad, Leila ;

Bumpstead, Suzannah ;

Baidoo, Leonard ;

Baldassano, Robert N. ;

Barclay, Murray ;

Bayless, Theodore M. ;

Brand, Stephan ;

Buening, Carsten ;

Colombel, Jean-Frederic ;

Denson, Lee A. ;

De Vos, Martine ;

Dubinsky, Marla ;

Edwards, Cathryn ;

Ellinghaus, David ;

Fehrmann, Rudolf S. N. ;

Floyd, James A. B. ;

Florin, Timothy ;

Franchimont, Denis ;

Franke, Lude ;

Georges, Michel ;

Glas, Juergen ;

Glazer, Nicole L. ;

Guthery, Stephen L. ;

Haritunians, Talin ;

Hayward, Nicholas K. ;

Hugot, Jean-Pierre ;

Jobin, Gilles ;

Laukens, Debby ;

Lawrance, Ian ;

Lemann, Marc ;

Levine, Arie ;

Libioulle, Cecile ;

Louis, Edouard ;

McGovern, Dermot P. ;

Milla, Monica ;

Montgomery, Grant W. ;

Morley, Katherine I. ;

Mowat, Craig .

NATURE GENETICS, 2011, 43 (03) :246-U94

[6]

Lack of a role for type I and type II interferons in the resolution of rotavirus-induced diarrhea and infection in mice [J].

Angel, J ;

Franco, MA ;

Greenberg, HB ;

Bass, D .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1999, 19 (06) :655-659

[7]

STING-Dependent Type I IFN Production Inhibits CellMediated Immunity to Listeria monocytogenes [J].

Archer, Kristina A. ;

Durack, Juliana ;

Portnoy, Daniel A. .

PLOS PATHOGENS, 2014, 10 (01)

[8]

Rotavirus NSP1 Mediates Degradation of Interferon Regulatory Factors through Targeting of the Dimerization Domain [J].

Arnold, Michelle M. ;

Barro, Mario ;

Patton, John T. .

JOURNAL OF VIROLOGY, 2013, 87 (17) :9813-9821

[9]

The Battle between Rotavirus and Its Host for Control of the Interferon Signaling Pathway [J].

Arnold, Michelle M. ;

Sen, Adrish ;

Greenberg, Harry B. ;

Patton, John T. .

PLOS PATHOGENS, 2013, 9 (01)

[10]

Diversity of Interferon Antagonist Activities Mediated by NSP1 Proteins of Different Rotavirus Strains [J].

Arnold, Michelle M. ;

Patton, John T. .

JOURNAL OF VIROLOGY, 2011, 85 (05) :1970-1979

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