Receptor mutation is not a common mechanism of naturally occurring glucocorticoid resistance in leukaemia cell lines

被引：20

作者：

Beesley, Alex H. ^{[1
]}

Weller, Renae E. ^{[1
]}

Senanayake, Saranga ^{[1
]}

Welch, Mathew ^{[1
]}

Kees, Ursula R. ^{[1
]}

机构：

[1] Univ Western Australia, Ctr Child Hlth Res, Telethon Inst Child Hlth Res, Div Childrens Leukaemia & Canc Res, Perth, WA 6009, Australia

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Acute lymphoblastic leukaemia; Glucocorticoid receptor; Drug resistance; Relapse; Mutation; ACUTE LYMPHOBLASTIC-LEUKEMIA; IN-VITRO; DRUG-RESISTANCE; CHILDHOOD LEUKEMIA; GENE; EXPRESSION; IDENTIFICATION; CHILDREN; HETEROZYGOSITY; POLYMORPHISMS;

D O I：

10.1016/j.leukres.2008.08.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Glucocorticoids (GCs) are among the most important drugs for the treatment of acute lymphoblastic leukaemia (ALL). Cell lines cultured in high GC concentrations typically contain mutated glucocorticoid receptor (GR), something that is rarely found in primary ALL specimens. We studied naturally occurring mechanisms of GC resistance and examined sensitivity to CC in 15 T-ALL cell lines grown without prior exposure to drugs. Resistance could not be attributed 10 Mutations in GR or variations in levels of its expression. We conclude that this Panel of cell lines provides a Suitable in vitro model since it reflects GC resistance in primary ALL. (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：321 / 325

页数：5

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