Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus

被引：29

作者：

Avdic, Selmir ^{[1
]}

McSharry, Brian P. ^{[1
]}

Slobedman, Barry ^{[1
,2
]}

机构：

[1] Univ Sydney, Human Cytomegalovirus Res Grp, Discipline Infect Dis & Immunol, Camperdown, NSW 2006, Australia

[2] Westmead Millennium Inst, Ctr Virus Res, Westmead, NSW, Australia

来源：

FRONTIERS IN MICROBIOLOGY | 2014年 / 5卷

关键词：

dendritic cells; cytomegalovirus; interleukin; 10; immunomodulation; virus replication and latency; I HEAVY-CHAINS; T-CELLS; INDOLEAMINE 2,3-DIOXYGENASE; HUMAN INTERLEUKIN-10; INHIBITS MATURATION; LATENT PHASE; INFECTION; REACTIVATION; HOMOLOG; IMMUNOMODULATION;

D O I：

10.3389/fmicb.2014.00337

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Human cytomegalovirus (HCMV), a clinically important beta-herpesvirus, is a master of evasion and modulation of the host immune system, including inhibition of a number of dendritic cell (DC) functions. DCs play a central role in co-ordination of the immune response against pathogens and any disturbance of DCs functions can result in a cascade effect on a range of immune cells. Recently, the HCMV gene UL111A, which encodes viral homologs of human interleukin 10, has been identified as a strong suppressor of a number of DCs functions. In this mini review, we focus on HCMV-encoded viral IL-10-mediated inhibitory effects on DCs and implications for the development of an effective HCMV vaccine.

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页数：5

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