Commitment to gametocytogenesis in Plasmodium falciparum

被引：66

作者：

Dyer, M ^{[1
]}

Day, KP ^{[1
]}

机构：

[1] Univ Oxford, Dept Zool, Wellcome Trust Ctr Epidemiol Infect Dis, Oxford OX1 3PS, England

来源：

PARASITOLOGY TODAY | 2000年 / 16卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0169-4758(99)01608-7

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

To achieve transmission, a subpopulation of sexually dividing bloodstream forms of the human malaria parasite Plasmodium falciparum withdraws from the cell cycle to develop into gametocytes - cells specialized for sexual reproduction and invasion of the mosquito vector. For natural selection to maximize transmission to new hosts, a balance must have evolved between asexual replication and sexual differentiation; Here, Mike Dyer and Karen Day consider observations an the process of commitment to gametocytogenesis and use this information as the framework for a model that begins to explain the control of the dynamics between asexual and sexual development.

引用

页码：102 / 107

页数：6

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