Heparan sulfate regulation of progenitor cell fate

被引：50

作者：

Cool, Simon M.

Nurcombe, Victor

机构：

[1] Inst Mol & Cell Biol, Lab Stem Cells & Tissue Repair, Singapore 138673, Singapore

[2] Natl Univ Singapore, Yoo Lin Sch Med, Dept Orthopaed Surg, Singapore 119074, Singapore

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2006年 / 99卷 / 04期

关键词：

stem cell; proliferation; differentiation; lineage; growth factors; extracellular matrix;

D O I：

10.1002/jcb.20936

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Currently there is an intense effort being made to elucidate the factors that control stem and progenitor cell fate. Developments in our understanding of the FGF/FGFR pathway and its role as an effector of stem cell pluripotency have heightened expectations that a therapeutic use for stem cells will move from a possibility to a probability. Mounting evidence is revealing the molecular mechanisms by which fibroblast growth factor (FGF) signaling, together with a large number of other growth and adhesive factors, is controlled by the extracellular sugar, heparan sulfate (HS). What has resulted is a novel means of augmenting and thus regulating the growth factor control of stem and progenitor cell fate. Here, we review the numerous bioactivities of HS, and the development of strategies to implement HS-induced control of cell fate decisions.

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收藏

页码：1040 / 1051

页数：12

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