Double-positive maternal serum screening results for Down syndrome and open neural tube defects: An indicator for fetal structural or chromosomal abnormalities and adverse obstetric outcomes

被引:31
作者
Chitayat, D
Farrell, SA
Huang, TH
Meier, C
Wyatt, PR
Summers, AM
机构
[1] Univ Toronto, Prenatal Diag & Med Genet Program, Mt Sinai Hosp, Toronto, ON M5G 1Z5, Canada
[2] Credit Valley Hosp, Toronto, ON, Canada
[3] N York Gen Hosp, Toronto, ON, Canada
关键词
maternal serum screening; double-positive screening result; fetal abnormality; chromosomal abnormality; adverse obstetric outcome;
D O I
10.1067/mob.2002.125240
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: The study was designed to evaluate whether double positive maternal serum screening results for Down syndrome and open neural tube defects indicate an increased risk of adverse perinatal outcome. STUDY DESIGN: A retrospective case-control study was conducted. In a cohort of 170,394 women who underwent maternal serum triple screening in Ontario, Canada, between October 1995 and September 1998, 189 women received positive screening results for both Down syndrome and neural tube defects. Each case was matched to 5 control subjects who had negative screening results for test center, maternal age, and specimen date. The risks for adverse perinatal outcomes were compared. RESULTS: Women with double-positive screening results had significantly higher risks of having fetuses with structural abnormalities (odds ratio, 14.5) and chromosomal anomalies (odds ratio, 36.3). They also had higher risks of having preeclampsia (odds ratio, 6.7), small-for-gestational age (odds ratio, 9.7), preterm delivery (odds ratio, 5.9), miscarriage, and intrauterine fetal death (odds ratio, 11.8). CONCLUSION: Double-positive maternal serum screening results are associated with fetal structural and chromosomal abnormalities and/or adverse pregnancy outcomes. Close fetal and maternal surveillance are indicated when such pregnancies are identified.
引用
收藏
页码:758 / 763
页数:6
相关论文
共 24 条
[1]  
Benn PA, 1997, PRENATAL DIAG, V17, P282, DOI 10.1002/(SICI)1097-0223(199703)17:3<282::AID-PD62>3.0.CO
[2]  
2-H
[3]  
BERM PA, 1996, OBSTET GYNECOL, V87, P217
[4]   RAISED MATERNAL SERUM ALPHA-FETOPROTEIN IN THE ABSENCE OF FETAL-ABNORMALITY PLACENTAL FINDINGS - A QUANTITATIVE MORPHOMETRIC STUDY [J].
BOYD, PA ;
KEELING, JW .
PRENATAL DIAGNOSIS, 1986, 6 (05) :369-373
[5]  
BROCK DJH, 1977, LANCET, V1, P700
[6]   FETAL KARYOTYPING FOR CHROMOSOME-ABNORMALITIES AFTER AN UNEXPLAINED ELEVATED MATERNAL SERUM ALPHA-FETOPROTEIN SCREENING [J].
FEUCHTBAUM, LB ;
CUNNINGHAM, G ;
WALLER, K ;
LUSTIG, LS ;
TOMPKINSON, DG ;
HOOK, EB .
OBSTETRICS AND GYNECOLOGY, 1995, 86 (02) :248-254
[8]  
Groli C, 1996, PRENATAL DIAG, V16, P685, DOI 10.1002/(SICI)1097-0223(199608)16:8<685::AID-PD907>3.3.CO
[9]  
2-U
[10]   ADVERSE PERINATAL OUTCOME IN PATIENTS SCREEN-POSITIVE FOR NEURAL-TUBE DEFECTS AND FETAL DOWN-SYNDROME [J].
GROSS, SJ ;
PHILLIPS, OP ;
SHULMAN, LP ;
BRIGHT, NL ;
DUNGAN, JS ;
SIMPSON, JL ;
ELIAS, S .
PRENATAL DIAGNOSIS, 1994, 14 (07) :609-613