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Estrogen and/or progesterone administered systemically or to the amygdala can have anxiety-reducing, fear-reducing, and pain-reducing effects in ovariectomized rats
被引:138
作者:
Frye, CA
Walf, AA
机构:
[1] SUNY Albany, Dept Psychol, Dept Biol Sci, Albany, NY 12222 USA
[2] SUNY Albany, Ctr Res Neurosci, Albany, NY 12222 USA
关键词:
D O I:
10.1037/0735-7044.118.2.306
中图分类号:
B84 [心理学];
C [社会科学总论];
Q98 [人类学];
学科分类号:
03 ;
0303 ;
030303 ;
04 ;
0402 ;
摘要:
Estrogen (E-2) and/or progesterone (P) in the amygdala may influence anxiety, fear, and pain behaviors. Ovariectomized rats were administered subcutaneous or intra-amygdala vehicle, E-2, P, or E-2 + P: Effects on open field, elevated plus-maze, defensive freezing, and hot-plate task performance were observed. Subcutaneous E. + P or intra-amygdala E2, P, or E2 + P increased open field central entries and open arm time in the plus-maze compared with vehicle. Subcutaneous or intra-amygdala E-2, P, or E2 + P decreased time spent freezing postshock compared with vehicle. Subcutaneous or intra-amygdala E2 + P increased latencies to lick paws compared with vehicle. Thus, E2 and P may have effects in the amygdala to decrease anxiety, fear, and/or pain responses.
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页码:306 / 313
页数:8
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