Estrogen and/or progesterone administered systemically or to the amygdala can have anxiety-reducing, fear-reducing, and pain-reducing effects in ovariectomized rats

被引:138
作者
Frye, CA
Walf, AA
机构
[1] SUNY Albany, Dept Psychol, Dept Biol Sci, Albany, NY 12222 USA
[2] SUNY Albany, Ctr Res Neurosci, Albany, NY 12222 USA
关键词
D O I
10.1037/0735-7044.118.2.306
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Estrogen (E-2) and/or progesterone (P) in the amygdala may influence anxiety, fear, and pain behaviors. Ovariectomized rats were administered subcutaneous or intra-amygdala vehicle, E-2, P, or E-2 + P: Effects on open field, elevated plus-maze, defensive freezing, and hot-plate task performance were observed. Subcutaneous E. + P or intra-amygdala E2, P, or E2 + P increased open field central entries and open arm time in the plus-maze compared with vehicle. Subcutaneous or intra-amygdala E-2, P, or E2 + P decreased time spent freezing postshock compared with vehicle. Subcutaneous or intra-amygdala E2 + P increased latencies to lick paws compared with vehicle. Thus, E2 and P may have effects in the amygdala to decrease anxiety, fear, and/or pain responses.
引用
收藏
页码:306 / 313
页数:8
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