Direct and Regioselective C-H Alkenylation of Tetrahydropyrido[1,2-a]pyrimidines

被引：69

作者：

Cheng, Dachen ^{[1
]}

Gallagher, Timothy ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 12期

关键词：

PALLADIUM(II) ACETATE; DIRECT ARYLATION; 2(1H)-PYRIDONE DERIVATIVES; BOND FUNCTIONALIZATION; AROMATIC SUBSTITUTION; HECK REACTION; OLEFINS; ACTIVATION; ARENES; INDOLES;

D O I：

10.1021/ol900627q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The electrophilic C-H palladation and Heck-type alkenylation of the tetrahydro[1,2-a]pyrimidine scaffold leads to exclusive formation of the C(7) adducts, and this palladium-catalyzed process is applicable to a broad range of alkenyl components. Mechanistic studies suggest that palladation is selective for C(7), and there was no evidence for C(9) metalation; the latter corresponds to the pathway observed previously with N-methylpyridone.

引用

页码：2639 / 2641

页数：3

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