Imaging Alzheimer's disease pathology: one target, many ligands

被引：53

作者：

Lockhart, Andrew ^{[1
]}

机构：

[1] Addenbrookes Hosp, GlaxoSmithKline, Addenbrookes Ctr Clin Invest, Cambridge CB2 2GG, England

来源：

DRUG DISCOVERY TODAY | 2006年 / 11卷 / 23-24期

关键词：

D O I：

10.1016/j.drudis.2006.10.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Over the past five years there has been a surge of interest in using positron emission tomography (PET) to determine the in vivo density of the senile plaque, a key pathological feature of Alzheimer's disease. The development of the tracers [C-11]-PIB, [C-11]-SB13 and [F-18]-FDDNP has coincided with drug strategies aimed at altering the brain metabolism of amyloid-beta peptides. The evolution of these novel ligands serves not only as an excellent example of how rapidly imaging technologies can progress but also as a reminder that the fundamental biological knowledge, which is necessary to fully interpret the PET data, can be left trailing behind.

引用

页码：1093 / 1099

页数：7

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