The SR protein family: Pleiotropic functions in pre-mRNA splicing

被引：195

作者：

Valcarcel, J ^{[1
]}

Green, MR ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS, MED CTR, PROGRAM MOL MED, HOWARD HUGHES MED INST, WORCESTER, MA 01605 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1996年 / 21卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0968-0004(96)10039-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A family of proteins with arginine-serine-rich domains has recently come into the limelight of studies on the mechanisms of constitutive and regulated pre-mRNA splicing. Implicated in an ever increasing variety of functions, these proteins act as driving forces during spliceosome assembly and also play decisive roles in alternative splice-site selection, suggesting that they are crucial players in the regulation of splicing during cell differentiation and development.

引用

页码：296 / 301

页数：6

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