What is the importance of the immunological synapse?

被引：221

作者：

Davis, DM

Dustin, ML

机构：

[1] Univ London Imperial Coll Sci & Technol, Dept Biol Sci, London SW7 2AZ, England

[2] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA

[3] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

来源：

TRENDS IN IMMUNOLOGY | 2004年 / 25卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/j.it.2004.03.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The immunological synapse (IS) has proved to be a stimulating concept, particularly in provoking discussion on the similarity of intercellular communication controlling disparate biological processes. Recent studies have clarified some of the underlying molecular mechanisms and functions of the IS. For both T cells and natural killer (NK) cells, assembly of the IS can be described in stages with distinct cytoskeletal requirements. Functions of the IS vary with circumstance and include directing secretion and integrating positive and negative signals to determine the extent of response.

引用

收藏

页码：323 / 327

页数：5

相关论文

共 53 条

[1]

Virus-driven evolution of natural killer cell receptors [J].

Arase, H ;

Lanier, LL .

MICROBES AND INFECTION, 2002, 4 (15) :1505-1512

[2]

B cells acquire antigen from target cells after synapse formation [J].

Batista, FD ;

Iber, D ;

Neuberger, MS .

NATURE, 2001, 411 (6836) :489-494

[3]

Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension [J].

Baumgart, T ;

Hess, ST ;

Webb, WW .

NATURE, 2003, 425 (6960) :821-824

[4]

Differential segregation in a cell-cell contact interface:: The dynamics of the immunological synapse [J].

Burroughs, NJ ;

Wülfing, C .

BIOPHYSICAL JOURNAL, 2002, 83 (04) :1784-1796

[5]

Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses [J].

Carlin, LM ;

Eleme, K ;

McCann, FE ;

Davis, DM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (10) :1507-1517

[6]

Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse [J].

Clark, RH ;

Stinchcombe, JC ;

Day, A ;

Blott, E ;

Booth, S ;

Bossi, G ;

Hamblin, T ;

Davies, EG ;

Griffiths, GM .

NATURE IMMUNOLOGY, 2003, 4 (11) :1111-1120

[7]

The human natural killer cell immune synapse [J].

Davis, DM ;

Chiu, I ;

Fassett, M ;

Cohen, GB ;

Mandelboim, O ;

Strominger, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15062-15067

[8]

Assembly of the immunological synapse for T cells and NK cells [J].

Davis, DM .

TRENDS IN IMMUNOLOGY, 2002, 23 (07) :356-363

[9]

A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts [J].

Dustin, ML ;

Olszowy, MW ;

Holdorf, AD ;

Li, J ;

Bromley, S ;

Desai, N ;

Widder, P ;

Rosenberger, F ;

van der Merwe, PA ;

Allen, PM ;

Shaw, AS .

CELL, 1998, 94 (05) :667-677

[10]

Identification of self through two-dimensional chemistry and synapses [J].

Dustin, ML ;

Bromley, SK ;

Davis, MM ;

Zhu, C .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2001, 17 :133-157

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