Cloning, RNA expression and chromosomal location of a mouse histamine H2 receptor gene

被引：25

作者：

Kobayashi, T

Inoue, I

Jenkins, NA

Gilbert, DJ

Copeland, NG

Watanabe, T

机构：

[1] KYUSHU UNIV,MED INST BIOREGULAT,DEPT MOL IMMUNOL,HIGASHI KU,FUKUOKA 81282,JAPAN

[2] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,MAMMALIAN GENET LAB,FREDERICK,MD 21702

来源：

GENOMICS | 1996年 / 37卷 / 03期

关键词：

D O I：

10.1006/geno.1996.0575

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A mouse histamine H2 receptor (H2R) gene was isolated from a mouse ES cell genomic DNA library. The gene encoded a 358-amino-acid protein and displayed a 95% homology with the rat histamine H2 receptor at the amino acid level. It had features characteristic of other G-protein-coupled receptors. Reverse transcriptase-polymerase chain reaction analysis of total RNA prepared from mouse tissues showed that the gene was highly expressed in stomach and moderately in brain and heart. A weak expression was also detected in liver. An interspecific backcross analysis revealed that the mouse H2R gene, designated Hrh2, was located in the central region of chromosome 13. (C) 1996 Academic Press, Inc.

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页码：390 / 394

页数：5

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