TACE inhibition: a new approach to treating inflammation

被引：29

作者：

Doggrell, SA ^{[1
]}

机构：

[1] Univ Queensland, Dept Physiol & Pharmacol, Sch Biomed Sci, Brisbane, Qld 4072, Australia

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2002年 / 11卷 / 07期

关键词：

arthritis; GW3333; TNF-alpha converting enzyme inhibition;

D O I：

10.1517/13543784.11.7.1003

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Clinical trials showing the benefits of reducing the effects of TNF-alpha in rheumatoid arthritis have highlighted the key role of the cytokine TNF-alpha in this inflammatory condition. A new approach to reducing the effects of TNF-alpha is to decrease its synthesis by inhibiting TNF-alpha converting enzyme with GW3333. In rat models of arthritis, GW3333 has some beneficial effects. Further longer-term studies of GW3333 in animal models are required to determine whether its benefit is maintained. TACE inhibition may represent a new approach to treating inflammation.

引用

页码：1003 / 1006

页数：4

共 23 条

[1]

BANTHON JM, 2000, NEW ENGL J MED, V343, P1586

[2]

Beutler BA, 1999, J RHEUMATOL, V26, P16

[3]

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells [J].

Black, RA ;

Rauch, CT ;

Kozlosky, CJ ;

Peschon, JJ ;

Slack, JL ;

Wolfson, MF ;

Castner, BJ ;

Stocking, KL ;

Reddy, P ;

Srinivasan, S ;

Nelson, N ;

Boiani, N ;

Schooley, KA ;

Gerhart, M ;

Davis, R ;

Fitzner, JN ;

Johnson, RS ;

Paxton, RJ ;

March, CJ ;

Cerretti, DP .

NATURE, 1997, 385 (6618) :729-733

[4]

INHIBITION OF CARTILAGE AND BONE DESTRUCTION IN ADJUVANT ARTHRITIS IN THE RAT BY A MATRIX METALLOPROTEINASE INHIBITOR [J].

CONWAY, JG ;

WAKEFIELD, JA ;

BROWN, RH ;

MARRON, BE ;

SEKUT, L ;

STIMPSON, SA ;

MCELROY, A ;

MENIUS, JA ;

JEFFREYS, JJ ;

CLARK, RL ;

MCGEEHAN, GM ;

CONNOLLY, KM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (02) :449-457

[5]

Conway JG, 2001, J PHARMACOL EXP THER, V298, P900

[6]

A METALLOPROTEASE INHIBITOR BLOCKS SHEDDING OF THE 80-KD TNF RECEPTOR AND TNF PROCESSING IN T-LYMPHOCYTES [J].

CROWE, PD ;

WALTER, BN ;

MOHLER, KM ;

OTTENEVANS, C ;

BLACK, RA ;

WARE, CF .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (03) :1205-1210

[7]

Anti-arthritic activity of hydroxamic acid-based pseudopeptide inhibitors of matrix metalloproteinases and TNF alpha processing [J].

DiMartino, M ;

Wolff, C ;

High, W ;

Stroup, G ;

Hoffman, S ;

Laydon, J ;

Lee, JC ;

Bertolini, D ;

Galloway, WA ;

Crimmin, MJ ;

Davis, M ;

Davies, S .

INFLAMMATION RESEARCH, 1997, 46 (06) :211-215

[8]

DIPHTHERIA-TOXIN ENDOCYTOSIS AND MEMBRANE TRANSLOCATION ARE DEPENDENT ON THE INTACT MEMBRANE-ANCHORED RECEPTOR (HB-EGF PRECURSOR) - STUDIES ON THE CELL-ASSOCIATED RECEPTOR CLEAVED BY A METALLOPROTEASE IN PHORBOL-ESTER-TREATED CELLS [J].

LANZREIN, M ;

GARRED, O ;

OLSNES, S ;

SANDVIG, K .

BIOCHEMICAL JOURNAL, 1995, 310 :285-289

[9]

Inhibition of matrix metalloproteinases and tumour necrosis factor α converting enzyme as adjuvant therapy in pneumococcal meningitis [J].

Leib, SL ;

Clements, JM ;

Lindberg, RLP ;

Heimgartner, C ;

Loeffler, JM ;

Pfister, LA ;

Täuber, MG ;

Leppert, D .

BRAIN, 2001, 124 :1734-1742

[10]

Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo [J].

Lewis, EJ ;

Bishop, J ;

Bottomley, KMK ;

Bradshaw, D ;

Brewster, M ;

Broadhurst, MJ ;

Brown, PA ;

Budd, JM ;

Elliott, L ;

Greenham, AK ;

Johnson, WH ;

Nixon, JS ;

Rose, F ;

Sutton, B ;

Wilson, K .

BRITISH JOURNAL OF PHARMACOLOGY, 1997, 121 (03) :540-546

← 1 2 3 →