A macrocyclic nitrosyl ruthenium complex is a NO donor that induces rat aorta relaxation

被引：59

作者：

Bonaventura, D

Oliveira, FD

Togniolo, V

Tedesco, AC

da Silva, RS

Bendhack, LM

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Quim & Fis, Farmacol Lab, BR-14040903 Ribeirao Preto, SP, Brazil

[2] Univ Sao Paulo, FFCLRP, Dept Quim, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 2004年 / 10卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

macrocyclic nitrosyl ruthenium complex; nitric oxide donor; sodium nitroprusside; vasorelaxation; rat aorta;

D O I：

10.1016/j.niox.2004.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The vasorelaxation induced by a nitrosyl macrocyclic ruthenium complex, proposed as a new nitric oxide (NO) carrier, was studied in rat isolated aorta. The compound trans-[RuCl([15]aneN(4))NO](2+) was characterized by elemental analysis, UV-visible spectrum, and infrared spectrum. Based on the electrochemical process, the reduction of the compound was followed by NO release, which was also observed using norepinephrine as a reducing agent and NO released was analyzed by a sensor. Vasorelaxation induced by this NO donor was studied and compared to those obtained with sodium nitroprusside (SNP). The relaxation induced by the compound was concentration-dependent in denuded rat aortas and occurred only in pre-contracted arteries with norepinephrine. The macrocyclic compound induced relaxation with a similar efficacy as SNP, although the potency of SNP was slightly greater. The time to reach maximum relaxation (595 s) was longer than that of SNP (195 s). Relaxation was completely abolished by oxyhemoglobin, a known NO scavenger. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：83 / 91

页数：9

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