Genetics of Lipid Traits and Relationship to Coronary Artery Disease

被引：27

作者：

Keenan, Tanya E. ^{[1
]}

Rader, Daniel J. ^{[2
]}

机构：

[1] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Cardiovasc Inst, Philadelphia, PA 19104 USA

来源：

CURRENT CARDIOLOGY REPORTS | 2013年 / 15卷 / 09期

关键词：

Genetics; GWAS; Mendelian randomization; Lipids; LDL-C; Lipoprotein(a); TG; HDL-C; PCSK9; DENSITY-LIPOPROTEIN CHOLESTEROL; TRIGLYCERIDE-RICH LIPOPROTEINS; ISCHEMIC-HEART-DISEASE; APOLIPOPROTEIN-C-III; FAMILIAL HYPERCHOLESTEROLEMIA; MENDELIAN RANDOMIZATION; MYOCARDIAL INFARCTION; ASSOCIATION ANALYSIS; HEPATIC LIPASE; RISK;

D O I：

10.1007/s11886-013-0396-9

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Despite the critical importance of plasma lipoproteins in the development of atherosclerosis, varying degrees of evidence surround the causal associations of lipoproteins with coronary artery disease (CAD). These causal contributions can be assessed by employing genetic variants as unbiased proxies for lipid levels. A relatively large number of low-density lipoprotein cholesterol (LDL-C) variants strongly associate with CAD, confirming the causal impact of this lipoprotein on atherosclerosis. Although not as firmly established, genetic evidence supporting a causal role of triglycerides (TG) in CAD is growing. Conversely, high-density lipoprotein cholesterol (HDL-C) variants not associated with LDL-C or TG have not yet been shown to be convincingly associated with CAD, raising questions about the causality of HDL-C in atherosclerosis. Finally, genetic variants at the LPA locus associated with lipoprotein(a) [Lp(a)] are decisively linked to CAD, indicating a causal role for Lp(a). Translational investigation of CAD-associated lipid variants may identify novel regulatory pathways with therapeutic potential to alter CAD risk.

引用

页数：10

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