Molecular and neuronal substrates for general anaesthetics

被引：588

作者：

Rudolph, U

Antkowiak, B

机构：

[1] Univ Zurich, Inst Pharmacol & Toxicol, CH-8057 Zurich, Switzerland

[2] Univ Tubingen, Dept Anaesthesiol, Sect Expt Anaesthesiol, D-72072 Tubingen, Germany

来源：

NATURE REVIEWS NEUROSCIENCE | 2004年 / 5卷 / 09期

关键词：

D O I：

10.1038/nrn1496

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although general anaesthesia has been of tremendous importance for the development of surgery, the underlying mechanisms by which this state is achieved are only just beginning to be understood in detail. In this review, we describe the neuronal systems that are thought to be involved in mediating clinically relevant actions of general anaesthetics, and we go on to discuss how the function of individual drug targets, in particular GABA(A)-receptor subtypes, can be revealed by genetic studies in vivo.

引用

收藏

页码：709 / 720

页数：12

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