Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain

被引：279

作者：

Kreuter, J ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Pharmazeut Technol, D-60439 Frankfurt, Germany

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2004年 / 4卷 / 05期

关键词：

nanoparticles; brain tumours; brain drug delivery; blood-brain barrier;

D O I：

10.1166/jnn.2003.077

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Poly(alkyl cyanoacrylate) nanoparticles enable the delivery of a number of drugs, including doxorubicin, loperamide, tubocurarine, the NMDA receptor antagonist MRZ 2/576, and the peptides dalargin and kytorphin across the blood-brain barrier (BBB) after coating with surfactants. However, only the surfactants polysorbate (Tween(R)) 20, 40, 60 and 80, and some poloxamers (Pluronic(R) F 68) can induce this uptake. The mechanism for the delivery across the BBB most likely is endocytosis via the LDL receptor by the endothelial cells lining the brain blood capillaries after injection of the nanoparticles into the blood stream. This endocytotic uptake seems to be mediated by the adsorption of apolipoprotein B and/or E adsorption from the blood. Thus, the nanoparticles could mimic lipoprotein particles and act as "Trojan Horses." The drug, then, may be released either within these cells followed by passive diffusion into the brain or be transported into the brain by transcytosis.

引用

收藏

页码：484 / 488

页数：5

相关论文

共 21 条

[1]

Interaction of poly(butylcyanoacrylate) nanoparticles with the blood-brain barrier in vivo and in vitro [J].

Alyaudtin, RN ;

Reichel, A ;

Löbenberg, R ;

Ramge, P ;

Kreuter, J ;

Begley, DJ .

JOURNAL OF DRUG TARGETING, 2001, 9 (03) :209-+

[2]

ALYAUTDIN R, 1995, EUR J PHARM BIOPHARM, V41, P44

[3]

Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles [J].

Alyautdin, RN ;

Petrov, VE ;

Langer, K ;

Berthold, A ;

Kharkevich, DA ;

Kreuter, J .

PHARMACEUTICAL RESEARCH, 1997, 14 (03) :325-328

[4]

Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles: an in situ brain perfusion study [J].

Alyautdin, RN ;

Tezikov, EB ;

Ramge, P ;

Kharkevich, DA ;

Begley, DJ ;

Kreuter, J .

JOURNAL OF MICROENCAPSULATION, 1998, 15 (01) :67-74

[5]

TOXICITY OF POLYALKYLCYANOACRYLATE NANOPARTICLES .2. DOXORUBICIN-LOADED NANOPARTICLES [J].

COUVREUR, P ;

KANTE, B ;

GRISLAIN, L ;

ROLAND, M ;

SPEISER, P .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1982, 71 (07) :790-792

[6]

Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacrylate) nanoparticles as a parenteral controlled release system [J].

Friese, A ;

Seiller, E ;

Quack, G ;

Lorenz, B ;

Kreuter, J .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2000, 49 (02) :103-109

[7]

Toxicological studies of doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma [J].

Gelperina, SE ;

Khalansky, AS ;

Skidan, IN ;

Smirnova, ZS ;

Bobruskin, AI ;

Severin, SE ;

Turowski, B ;

Zanella, FE ;

Kreuter, J .

TOXICOLOGY LETTERS, 2002, 126 (02) :131-141

[8]

GELPERINA SE, 2000, P 3 WORLD M APV APGI, P441

[9]

Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles [J].

Gulyaev, AE ;

Gelperina, SE ;

Skidan, IN ;

Antropov, AS ;

Kivman, GY ;

Kreuter, J .

PHARMACEUTICAL RESEARCH, 1999, 16 (10) :1564-1569

[10]

Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier [J].

Kreuter, J ;

Shamenkov, D ;

Petrov, V ;

Ramge, P ;

Cychutek, K ;

Koch-Brandt, C ;

Alyautdin, R .

JOURNAL OF DRUG TARGETING, 2002, 10 (04) :317-325