Cellular patterns of transcription factor expression in developing cortical Interneurons

被引：131

作者：

Cobos, Inma ^{[1
]}

Long, Jason E. ^{[1
]}

Thwin, Myo T. ^{[1
]}

Rubenstein, John L. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Psychiat, Nina Ireland Lab Dev Neurobiol, San Francisco, CA 94158 USA

来源：

CEREBRAL CORTEX | 2006年 / 16卷

关键词：

calretinin; GAD; inhibition; parvalbumin; somatostatin;

D O I：

10.1093/cercor/bhk003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Most gamma-aminobutyric acidergic interneurons in the neocortex and hippocampus are derived from subpallial progenitors in the medial ganglionic eminence and migrate tangentially to the pallium, where they differentiate into a diverse set of neuronal subtypes. Toward elucidating the mechanisms underlying the generation of interneuron diversity, we have studied in mice the expression patterns in differentiating and mature neocortical interneurons of 8 transcription factors, including 6 homeobox (Dlx1, Dlx2, Dlx5, Arx, Lhx6, Cux2), 1 basic helix-loop-helix, (NPAS1), and 1 HIP (MafB). Their patterns of expression change during interneuron differentiation and show distinct distributions within interneuron subpopulations in adult neacortex. This study is a first step to define the combinatorial codes of transcription factors that participate in regulating the specification and function of cortical interneuron subtypes.

引用

页码：I82 / I88

页数：7

共 55 条

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[2]

Lhx6 regulates the migration of cortical interneurons from the ventral telencephalon but does not specify their GABA phenotype [J].