Near infrared spectroscopy for noninvasive assessment of claudication

The purpose of this study was to explore the application of near-infrared spectroscopy (NIRS) to the assessment of peripheral arterial occlusive disease (PAOD). Muscle blood flow, oxygen consumption, arterial inflow capacity, O-2 resaturation, and recovery times were determined at rest, under ischemic and hyperemic conditions, and continuously during and after walking exercise in 11 claudicants and 15 nonclaudicants. Blood flow and oxygen consumption ((V) over dot O-2) at rest and blood flow following walking exercise did not differ significantly between claudicants and nonclaudicants. In contrast, (V) over dot O-2, after walking exercise was increased by a factor of 4.1 in claudicants compared to a factor of 1.7 in nonclaudicants. The oxygen resaturation rate after arterial occlusion and the oxygen resaturation rate after walking exercise were significantly lower in claudicants. Claudicants showed a higher degree of hemoglobin deoxygenation during walking exercise than nonclaudicants. A high postexercise (V) over dot O-2 is correlated with a low ankle-brachial index (ABI). The resaturation rates and recovery times following walking exercise and arterial occlusion correlated significantly with ABI parameters. A significant negative correlation was found between hemoglobin deoxygenation during exercise and the ABI parameters. A high correlation was observed between the oxygenated hemoglobin (O(2)Hb) recovery time and the ABI recovery time after walking exercise. NIRS appears to be an effective noninvasive method for assessing the imbalance between oxygen demand and oxygen delivery in the leg muscles of PAOD patients at rest and during exercise. (C) 1997 Academic Press.