sTRAIL levels and TRAIL gene polymorphisms in Chinese patients with fatty liver disease

被引：46

作者：

Yan, Xiaohua ^{[1
,2
]}

Xu, Liyun ^{[1
]}

Qi, Jianni ^{[1
]}

Liang, Xiaohong ^{[1
]}

Ma, Chunhong ^{[1
]}

Guo, Chun ^{[1
]}

Zhang, Lining ^{[1
]}

Sun, Wensheng ^{[1
]}

Zhang, Jiyun ^{[2
]}

Wei, Xiaoyi ^{[2
]}

Gao, Lifen ^{[1
]}

机构：

[1] Shandong Univ, Sch Med, Dept Immunol, Jinan 250012, Peoples R China

[2] Shandong Med Coll, Linyi 276002, Peoples R China

来源：

IMMUNOGENETICS | 2009年 / 61卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL); Single-nucleotide polymorphism (SNP); Fatty liver disease (FLD); NONALCOHOLIC STEATOHEPATITIS; MULTIPLE-SCLEROSIS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; INDUCED APOPTOSIS; SOLUBLE TRAIL; RISK-FACTORS; TNF-ALPHA; HEPATOCYTES; EXPRESSION;

D O I：

10.1007/s00251-009-0389-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily, and has been identified as a novel mediator of fatty liver disease (FLD). The aim of our study was to further investigate the relationship between TRAIL and FLD. We found that soluble TRAIL (sTRAIL) concentrations in non-alcoholic FLD (NAFLD) patients were significantly higher than those of controls, and that sTRAIL levels positively correlated with triglyceride concentrations in NAFLD patients. Our results also indicated that the AA/TT genotypes of TRAIL at 1525/1595 engendered a lower risk of FLD attack and a less severe form of steatosis for NAFLD patients in Chinese population. This study provides a means to test for susceptibility to FLD and may assist in the diagnosis of FLD. In addition, we found that 1525G/A and 1595C/T sites were in complete linkage disequilibrium in Chinese population. This might indicate a haplotype with high genetic frequency of TRAIL.

引用

页码：551 / 556

页数：6

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