Update on Survival in Osteosarcoma

被引：598

作者：

Anderson, Megan E. ^{[1
,2
]}

机构：

[1] Boston Childrens Hosp, Boston, MA 02115 USA

[2] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

来源：

ORTHOPEDIC CLINICS OF NORTH AMERICA | 2016年 / 47卷 / 01期

关键词：

Osteosarcoma; Survival; Prognosis; Limb salvage surgery; Systemic chemotherapy; Late effects; HIGH-GRADE OSTEOSARCOMA; NEOADJUVANT CHEMOTHERAPY; ADJUVANT CHEMOTHERAPY; PATHOLOGICAL FRACTURE; PROGNOSTIC-FACTORS; NONMETASTATIC OSTEOSARCOMA; PREOPERATIVE CHEMOTHERAPY; METASTATIC OSTEOSARCOMA; LOCALIZED OSTEOSARCOMA; HISTOLOGIC RESPONSE;

D O I：

10.1016/j.ocl.2015.08.022

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Osteosarcoma is the most common primary bone malignancy in children. Treatment has evolved to include systemic chemotherapy and local control surgery. Although survival improved initially in a drastic fashion with this approach, recent decades have seen little to no further gains in this area. Limb salvage surgery evolved with effective chemotherapy and advances in imaging, and continues to improve in the recent era. This article serves as a review of survival in high-grade osteosarcoma: prognostic factors, advances in chemotherapy and surgery, late effects of chemotherapy and surgery in survivors, and future directions.

引用

页码：283 / +

页数：12

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