The leader sequence triggers and enhances several functions of clusterin and is instrumental in the progression of human prostate cancer in vivo and in vitro

被引：22

作者：

Zhang, Qiang

Zhou, Wei

Kundu, Shilajit

Jang, Thomas L.

Yang, Ximing

Pins, Michael

Smith, Norm

Jovanovic, Borko

Xin, Dianqi

Liang, Lili

Guo, Yinglu

Lee, Chung

机构：

[1] Northwestern Univ, Dept Urol, Feinberg Sch Med, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA

[4] Northwestern Univ, Feinberg Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[5] Peking Univ, Hosp 1, Inst Urol, Beijing, Peoples R China

来源：

BJU INTERNATIONAL | 2006年 / 98卷 / 02期

关键词：

apoptosis; cyto-protection; leader sequence; clusterin; prostate cancer;

D O I：

10.1111/j.1464-410X.2006.06263.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

To investigate the role of the leader sequence (which during clusterin biosynthesis facilitates its proper post-translational processing and secretion) in the functional activities of clusterin, a ubiquitous secretory glycoprotein with many biological functions, reported to be pro-apoptotic and anti-apoptotic in target cells, but for which the dual mechanism remains unclear.

引用

收藏

页码：452 / 460

页数：9

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