Mechanisms of Disease: immunopathogenesis of celiac disease

被引：133

作者：

Jabri, Bana ^{[1
]}

Sollid, Ludvig M.

机构：

[1] Univ Chicago, Dept Pathol Med & Pediat, Chicago, IL 60637 USA

[2] Univ Oslo, N-0316 Oslo, Norway

[3] Rikshop Univ Hosp, Rikshosp, Radiumhosp Med Ctr, Oslo, Norway

来源：

NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY | 2006年 / 3卷 / 09期

关键词：

celiac disease; gluten; major histocompatibility complex; natural killer receptors; transglutaminase;

D O I：

10.1038/ncpgasthep0582

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Celiac disease is a genetic inflammatory disorder with autoimmune components that is induced by the ingestion of dietary gluten. Refractory sprue and enteropathy-associated T-cell lymphoma are rare but distinctive complications of the disease. Although the importance of the adaptive immune response to gluten has been well established, observations now also point towards a central role for the gluten-induced innate stress response in the pathogenesis of celiac disease and its malignant complications.

引用

页码：516 / 525

页数：10

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