The Effects of Bariatric Surgery on Colorectal Cancer Risk: Systematic Review and Meta-analysis

被引：67

作者：

Afshar, Sorena ^{[1
,2
]}

Kelly, Seamus B. ^{[2
]}

Seymour, Keith ^{[2
]}

Lara, Jose ^{[1
]}

Woodcock, Sean ^{[2
]}

Mathers, John C. ^{[1
]}

机构：

[1] Newcastle Univ, Human Nutr Res Ctr, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 5PL, England

[2] Northumbria Healthcare NHS Fdn Trust, North Tyneside Gen Hosp, Northumberland NE29 8NH, England

来源：

OBESITY SURGERY | 2014年 / 24卷 / 10期

基金：

英国医学研究理事会;

关键词：

Colorectal neoplasms; Obesity; Weight loss; Bariatric surgery; TERM WEIGHT-LOSS; MECHANISMS LINKING OBESITY; PHYSICAL-ACTIVITY; HETEROGENEITY; INFLAMMATION; PREVENTION; EXERCISE; MEN;

D O I：

10.1007/s11695-014-1359-y

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Obesity is an established risk factor for colorectal cancer (CRC) but the effects of bariatric surgery on CRC incidence are uncertain. A systematic review of six electronic databases identified 3691 articles. Four observational studies met our inclusion criteria and results were pooled using a random effects model. Meta-analysis of these four studies revealed that bariatric surgery was associated with a significantly (p = 0.004) lower CRC incidence (RR = 0.73, 95 % confidence interval, 0.58-0.90) when compared with obese non-operated individuals, i.e., bariatric surgery is associated with a 27 % lower CRC risk. However the evidence base is limited and these findings should be confirmed by future studies with improved designs.

引用

页码：1793 / 1799

页数：7

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