Low sensitivity of a whole-blood interferon-γ release assay for detection of active tuberculosis

被引：127

作者：

Dewan, Puneet K.

Grinsdale, Jennifer

Kawamura, L. Masae

机构：

[1] Ctr Dis Control & Prevent, Int Res & Programs Branch, Div Tuberculosis Eliminat, Natl Ctr HIV STD & TB Prevent, Atlanta, GA 30333 USA

[2] San Francisco Dept Publ Hlth, San Francisco, CA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2007年 / 44卷 / 01期

关键词：

D O I：

10.1086/509928

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The sensitivity of an interferon-g assay (Quantiferon-TB Gold; Cellestis) was evaluated for the detection of tuberculosis among 242 persons with suspected tuberculosis in San Francisco, California. Thirty-seven subjects had culture-confirmed tuberculosis. Excluding 1 indeterminate result, 23 (64%; 95% confidence interval, 48%-78%) of 36 subjects had positive results using the QuantiFERON-TB Gold assay. The 64% sensitivity suggests that the QuantiFERON-TB Gold assay should not be used alone to exclude active tuberculosis.

引用

页码：69 / 73

页数：5

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