Homocysteine and Alzheimer's disease: A modifiable risk?

被引：47

作者：

Dwyer, BE

Raina, AK

Perry, G

Smith, MA

机构：

[1] VAM&ROC, Res Serv 151, White River Jct, VT 05009 USA

[2] Dartmouth Coll Sch Med, Dept Med Neurol, Hanover, NH USA

[3] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2004年 / 36卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; homocysteine; oxidative stress; heme oxygenase; cystathionine beta-synthase; herne; iron; ferritin; free radicals;

D O I：

10.1016/j.freeradbiomed.2004.03.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A hypothesis is proposed that reconciles the epidemiological observation of elevated homocysteine in Alzheimer's disease (AD) with clinical features of the disease, particularly evidence of increased oxidative stress. We propose homocysteine is involved in an iron dysregulation/oxidative stress cycle that has a central role in the pathogenesis of AD. The implications of the hypothesis and some strategies for testing it are discussed. (C) 2004 Elsevier Inc. All rights reserved.

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页码：1471 / 1475

页数：5

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