Parkinson's patients (PD) made pro- and antisaccades: In the no-delay condition, the target appeared concurrent with the GO signal. In the delay condition, the tail-let appeared before the signal for movement. Second. we probed spatial working memory in PD, Subjects looked to the remembered locations of sequential targets. In the no-delay pro-accade condition. PD had faster reaction times, made more express saccades. and exhibited hypometria. In the no-delay antisaccade condition. PD had longer reaction times and made more direction errors, In the delay tasks. PD made more direction error, and had more difficulty withholding a movement. PD made more sequencing errors in the spatial working memory task. These findings are consistent with a basal ganglia pathophysiology influencing eye movement processing in the frontal cortex. (C) 2002 Elsevier Science (USA).
