Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)

被引：82

作者：

Heaney, Liam G. ^{[1
]}

Djukanovic, Ratko ^{[2
]}

Woodcock, Ashley ^{[3
]}

Walker, Samantha ^{[4
,5
]}

Matthews, John G. ^{[5
]}

Pavord, Ian D. ^{[6
]}

Bradding, Peter ^{[7
]}

Niven, Robert ^{[3
]}

Brightling, Chris E. ^{[7
]}

Chaudhuri, Rekha ^{[8
]}

Arron, Joseph R. ^{[5
]}

Choy, David F. ^{[5
]}

Cowan, Douglas ^{[8
]}

Mansur, Adel ^{[9
]}

Menzies-Gow, Andrew ^{[10
]}

Adcock, Ian ^{[11
]}

Chung, Kian F. ^{[11
]}

Corrigan, Chris ^{[12
]}

Coyle, Peter ^{[2
]}

Harrison, Timothy ^{[13
]}

Johnston, Sebastian ^{[11
]}

Howarth, Peter

Lordan, James ^{[14
]}

Sabroe, Ian ^{[15
]}

Bigler, Jeannette ^{[16
]}

Smith, Dirk ^{[16
]}

Catley, Matthew ^{[17
]}

May, Richard ^{[17
]}

Pierre, Lisa ^{[18
]}

Stevenson, Chris ^{[18
]}

Crater, Glenn ^{[19
]}

Keane, Frank ^{[20
]}

Costello, Richard W. ^{[21
]}

Hudson, Val ^{[22
]}

Supple, David ^{[22
]}

Hardman, Tim ^{[23
]}

机构：

[1] Queens Univ Belfast, Ctr Infect & Immun, Belfast BT9 7AB, Antrim, North Ireland

[2] Univ Southampton, Acad Unit Clin & Expt Sci, Southampton, Hants, England

[3] Univ Manchester, Manchester Acad Hlth Sci Ctr, Inst Inflammat & Repair, Manchester, Lancs, England

[4] Asthma UK, London, England

[5] Genentech Inc, San Francisco, CA 94080 USA

[6] Univ Oxford, Nuffield Dept Med, Oxford, England

[7] Univ Leicester, Inst Lung Hlth, Dept Infect Immun & Inflammat, Leicester, Leics, England

[8] Greater Glasgow Hlth Board, Glasgow, Lanark, Scotland

[9] Heart England NHS Fdn Trust, Birmingham, W Midlands, England

[10] Royal Brompton & Harefield NHS Fdn Trust, London, England

[11] Univ London Imperial Coll Sci Technol & Med, London, England

[12] Kings Coll London, London, England

[13] Univ Nottingham, Nottingham NG7 2RD, England

[14] Newcastle Tyne NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England

[15] Univ Sheffield, Sch Med & Biomed Sci, Sheffield, S Yorkshire, England

[16] Amgen Inc, Thousand Oaks, CA USA

[17] Astra Zeneca, London, England

[18] Jannsen Res & Dev LLC, London, England

[19] Aerocrine AB, Solna, Sweden

[20] Vitalograph Inc, Ennis, Ireland

[21] Royal Coll Surgeons Ireland, Dept Med, Dublin 2, Ireland

[22] Publ & Patient Representat, London, England

[23] Niche Sci & Technol, Richmond, Surrey, England

来源：

THORAX | 2016年 / 71卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1136/thoraxjnl-2015-207326

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite biomarker strategy to optimise CS dose; this will also address what proportion of patients with severe asthma have persistent symptoms without eosinophilic airways inflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies.

引用

页码：187 / 189

页数：3

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