Racemic but Tropos (chirally flexible) BIPHEP ligands for Rh(I)-complexes:: Highly enantioselective ene-type cyclization of 1,6-enynes

被引：63

作者：

Mikami, K ^{[1
]}

Kataoka, S ^{[1
]}

Yusa, Y ^{[1
]}

Aikawa, K ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Appl Chem, Tokyo 1528552, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 21期

关键词：

D O I：

10.1021/ol048604l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The tropos (chirally flexible) or atropos (chirally rigid) nature of BIPHEP-Rh complexes at room temperature critically depends on the amines complexed. The aliphatic DPEN complex is atropos, whereas the aromatic DABN complex is tropos. BIPHEP-Rh chirality can thus be controlled by DABN at room temperature. The amine-free BIPHEP-Rh complex is tropos. At 5 degreesC, even amine-free BIPHEP-Rh complexes are atropos and hence can be used as enantiopure catalysts to give high enantioselectivity in ene-type cyclization of 1,6-enynes.

引用

页码：3699 / 3701

页数：3

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