Keeping fingers crossed: heterochromatin spreading through interdigitation of nucleosome arrays

被引：36

作者：

Grigoryev, SA ^{[1
]}

机构：

[1] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Biochem & Mol Biol, Hershey, PA 17033 USA

来源：

FEBS LETTERS | 2004年 / 564卷 / 1-2期

关键词：

heterochromatin; nucleosome; histone; higher order folding; chromatin 3D structure;

D O I：

10.1016/S0014-5793(04)00258-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interphase eukaryotic nuclei contain diffuse euchromatin and condensed heterochromatin. Current textbook models suggest that chromatin condensation occurs via accordion-type compaction of nucleosome zigzag chains. Recent studies have revealed several structural aspects that distinguish the highly compact state of condensed heterochromatin. These include an extensive lateral self-association of chromatin fibers, prominent nucleosome linker 'stems', and special protein factors that promote chromatin self-association. Here I review the molecular and structural determinants of chromatin compaction and discuss how heterochromatin spreading may be mediated by lateral self-association of zigzag nucleosome arrays. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：4 / 8

页数：5

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