Photopolymerization of methacrylated chitosan/PNIPAAm hybrid dual-sensitive hydrogels as carrier for drug delivery

被引：78

作者：

Han, Jing ^{[1
]}

Wang, Kemin ^{[1
]}

Yang, Dongzhi ^{[1
]}

Nie, Jun ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2009年 / 44卷 / 03期

关键词：

Hybrid hydrogel; Chitosan; Poly(N-isopropylacrylamide); Drug delivery; IN-VITRO; TEMPERATURE; RELEASE; CHITIN;

D O I：

10.1016/j.ijbiomac.2008.12.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A series of hybrid hydrogels based on glycidyl methacrylated chitosan (CS-GMA) and N-isopropylacrylamide (NIPAAm) were designed and prepared via photopolymerization technology. The hydrogels were characterized by Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC) and optical transmittance. The interior morphology of hydrogels was investigated by scanning electron microscopy (SEM). The swelling experiment results revealed that hybrid hydrogel exhibited combined pH and temperature sensitivities. Acid orange 8 (AO8) and 5-flurouracil (5-Fu) were selected as model drugs for examining their release from hydrogels. The results suggested that hydrogel composition and pH value of buffer solution had great influences on release profiles. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：229 / 235

页数：7

共 36 条

[1]

Recent advances on chitosan-based micro- and nanoparticles in drug delivery [J].