The unfolding story of the Escherichia coli Hsp70 DnaK:: is DnaK a holdase or an unfoldase?

被引：80

作者：

Slepenkov, SV ^{[1
]}

Witt, SN ^{[1
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Shreveport, LA 71130 USA

来源：

MOLECULAR MICROBIOLOGY | 2002年 / 45卷 / 05期

关键词：

D O I：

10.1046/j.1365-2958.2002.03093.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We discuss recent experiments that have illuminated individual steps in the reaction cycle of the Escherichia coli Hsp70 molecular chaperone DnaK. Using this new information, we comparetwo distinctly different global mechanisms of action - holding versus unfolding - and argue that the available evidencesuggests that DnaK is an unfoldase.

引用

页码：1197 / 1206

页数：10

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