A conformational study of ligands for omega modulatory sites of GABA(A) receptors by noesy NMR spectroscopy and distance geometry.

被引：7

作者：

Olivier, A ^{[1
]}

Sevrin, M ^{[1
]}

Durant, F ^{[1
]}

George, P ^{[1
]}

机构：

[1] SYNTHELABO RECH,LERS,DEPT RECH SNC,F-92225 BAGNEUX,FRANCE

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(97)00404-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Conformational analysis by NOESY NMR spectroscopy and Distance Geometry of an omega(1), selective (zolpidem) and a non selective (saripidem) ligand of omega modulatory sites suggests that the single set of conformations observed with zolpidem could be account for its omega, selective properties. The methodology applied in this study appears to be a powerful technique to explore conformational space of non-peptidic ligands of GABA, receptor subtypes. (C) 1997 Elsevier Science Ltd.

引用

页码：2277 / 2282

页数：6

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