1,3-dipolar cycloaddition approach to indolic aza-analogues of cephalotaxine

被引：15

作者：

Nyerges, M

Rudas, M

Bitter, I

Toke, L

Szantay, C

机构：

[1] TECH UNIV BUDAPEST, RES GRP, DEPT ORGAN CHEM TECHNOL, HUNGARIAN ACAD SCI, H-1521 BUDAPEST, HUNGARY

[2] CHEM WORKS GEDEON RICHTER LTD, SPECTROSCOP RES DIV, H-1475 BUDAPEST 10, HUNGARY

来源：

TETRAHEDRON | 1997年 / 53卷 / 09期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/S0040-4020(97)00037-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An indolic aza-analogue (14) of cephalotaxine has been prepared stereoselectively using 1,3-dipolar cycloaddition of azomethine ylide as a key step. The Pictet-Spengler reaction of the amine 10 resulted in the formation of an unusual heterocyclic product (11). The structure and stereochemistry of 11 and 14 were studied in detail by n.m.r. spectroscopic methods. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：3269 / 3280

页数：12

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