ACRP30, a new hormone controlling fat and glucose metabolism

被引：217

作者：

Tsao, TS

Lodish, HF

Fruebis, J

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

[3] Genset Corp, San Diego, CA 92121 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2002年 / 440卷 / 2-3期

关键词：

ACRP30 (adipocyte complement-related protein of 30 kDa); AdipoQ; adiponectin; obesity; diabetes; insulin resistance; lipid metabolism; glucose metabolism;

D O I：

10.1016/S0014-2999(02)01430-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adipocyte complement-related protein of 30 kDa (ACRP30) is a secreted serum protein expressed exclusively in differentiated adipocytes. Recent studies have indicated that its expression and serum levels are reduced in humans and animals with obesity and insulin resistance. Metabolic studies have demonstrated a role for ACRP30 in the regulation of glucose and lipid homeostasis. This review will describe the current literature on the biochemistry of ACRP30 and its physiological functions. We will also discuss issues that are relevant to the directions of future research. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：213 / 221

页数：9

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