Finding the genes that direct mammalian development - ENU mutagenesis in the mouse

被引：34

作者：

Anderson, KV ^{[1
]}

机构：

[1] Sloan Kettering Inst, Program Mol Biol, New York, NY 10021 USA

来源：

TRENDS IN GENETICS | 2000年 / 16卷 / 03期

关键词：

D O I：

10.1016/S0168-9525(99)01921-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genetic control of mammalian embryogenesis is not well understood. N-ethyl-N-nitrosourea (ENU) mutagenesis screens in the mouse provide a route to identify more of the genes that are required for mammalian development. The characterization of ENU-induced mutations can build on the resources provided by the mouse and human genome projects to help define the tissue interactions and signaling pathways that direct early mammalian development.

引用

页码：99 / 102

页数：4

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