Monoamine transporter gene polymorphisms affect susceptibility to depression and predict antidepressant response

被引:71
作者
Min, Wenjiao [1 ,2 ]
Li, Tao [1 ,3 ]
Ma, Xiaohong [1 ]
Li, Zhengyu [4 ]
Yu, Tao [1 ]
Gao, Dong [1 ]
Zhang, Bo [1 ]
Yun, Yang [1 ]
Sun, Xueli [1 ]
机构
[1] Sichuan Univ, W China Hosp, Mental Hlth Ctr, Chengdu 610041, Peoples R China
[2] Chengdu Fourth Peoples Hosp, Chengdu 610041, Peoples R China
[3] Inst Psychiat, Med Res Ctr Social Genet & Dev Psychiat MRC SGDP, Div Psychol Med, London, England
[4] Sichuan Univ, W China Hosp 2, Dept Gynecol & Obstet, Chengdu 610041, Peoples R China
关键词
Antidepressant response; Depression; Gene polymorphisms; 5-HTT; NET; SEROTONIN TRANSPORTER; NOREPINEPHRINE TRANSPORTER; MAJOR DEPRESSION; PROMOTER POLYMORPHISM; 5-HTTLPR POLYMORPHISM; JAPANESE POPULATION; ALLELIC VARIANTS; VARIABLE NUMBER; MOOD DISORDERS; MENTAL-HEALTH;
D O I
10.1007/s00213-009-1550-3
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Serotonin transporter (5-HTT) and norepinephrine transporter (NET) are the primary targets of many antidepressants. We aimed to determine the potential correlations of 5-HTT/NET gene polymorphisms with the susceptibility to depression and the antidepressant response to selective serotonin reuptake inhibitors (SSRIs) or dual selective serotonin/norepinephrine reuptake inhibitors (SNRIs). A total of 579 depressed patients and 437 healthy controls, all of Chinese Han region, were collected and genotyped by polymerase chain reactions (PCR). All patients were under treatment of SSRI or SNRI for 6 weeks, and were evaluated using a 17-item Hamilton Depression Rating Scale (HAMD). Five hundred sixty-seven of 579 patients completed the total treatment, of which 362 were in SSRI and 205 in SNRI group. It was shown that the NET-T182C, interacting with 5-HTTLPR, was associated with the susceptibility to depression. Patients with both NET-T182C C/C and 5-HTTLPR S/S genotypes had lower baseline HAMD scores. Patients with 5-HTTLPR L/L or STin2 12/12 genotype experienced better clinical response to the SSRI treatment. Besides, the STin2 12/12 carriers showed a superior reduction to HAMD scores over treatment period. No correlation between NET T182C/G1287A polymorphisms and antidepressant response was observed. Our study revealed a positive association of the NET-T182C polymorphism with susceptibility to and severity of depression, and a positive association between the 5-HTT polymorphisms and the antidepressant response to SSRI. Combinations of these polymorphisms provided some potential gene-gene interaction effects. These findings might be of some clinical values in optimization of depression treatment.
引用
收藏
页码:409 / 417
页数:9
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