A reeler mutant mouse with a new, spontaneous mutation in the reelin gene

被引：17

作者：

Andersen, TE

Finsen, B

Goffinet, AM

Issinger, OG

Boldyreff, B

机构：

[1] Univ So Denmark, Dept Biochem & Mol Biol, DK-5230 Odense, Denmark

[2] Univ So Denmark, DK-5000 Odense C, Denmark

[3] Univ Louvain, Sch Med, Dev Genet Unit, B-1200 Brussels, Belgium

来源：

MOLECULAR BRAIN RESEARCH | 2002年 / 105卷 / 1-2期

关键词：

reelin; Reln; mutation; neuronal migration;

D O I：

10.1016/S0169-328X(02)00389-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In one of our mouse colonies a reeler-like phenotype appeared spontaneously. The brain histology was identical to the known reeler phenotype. Northern and Western blot analysis and a complementation test showed that the defect is located to the reelin gene. Southern blot and PCR analysis together with information obtained from sequence databases revealed that this defective reelin gene had an approximately 24-kb intragenic deletion comprising exons 13-20. (C) 2002 Elsevier Science B.V. All rights reserved.

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收藏

页码：153 / 156

页数：4

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