Effects of bioactive lipids and lipoproteins on bone

被引：110

作者：

Tintut, Yin ^{[1
]}

Demer, Linda L. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, Div Cardiol, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2014年 / 25卷 / 02期

基金：

美国国家卫生研究院;

关键词：

HIGH-FAT DIET; LOW-DENSITY LIPOPROTEINS; PARATHYROID-HORMONE; OXIDATIVE STRESS; MINERAL DENSITY; VASCULAR CALCIFICATIONS; ATHEROGENIC DIET; ARTERIAL-WALL; ATHEROSCLEROSIS; RECEPTOR;

D O I：

10.1016/j.tem.2013.10.001

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Although epidemiological studies from the past two decades show a link between atherosclerotic vascular disease and bone loss, that is independent of age, the mechanism is still unclear. This review focuses on evidence that suggests a role for atherogenic lipids and lipoproteins in the pathogenesis of bone loss, including direct effects of these bioactive lipids/lipoproteins on bone cells, inhibiting osteoblastic differentiation and promoting osteoclastic differentiation. It also addresses recent evidence that suggests that bioactive lipids blunt the effects of bone anabolic agents such as teriparatide and bone morphogenetic proteins. Systemic and intracellular oxidant stress and inflammation are implicated in mediating the effects of bioactive lipids/lipoproteins.

引用

页码：53 / 59

页数：7

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