Inhibitory effect of ginsenoside Rg5 and its metabolite ginsenoside Rh3 in an oxazolone-induced mouse chronic dermatitis model

被引：82

作者：

Shin, Yong-Wook ^{[1
]}

Bae, Eun-Ah ^{[1
]}

Kim, Dong-Hyun ^{[1
]}

机构：

[1] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2006年 / 29卷 / 08期

关键词：

ginsenoside Rg5; ginsenoside Rh3; COX-2; IFN-gamma; psoriasis;

D O I：

10.1007/BF02968253

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of a main constituent ginsenoside Rg5 isolated from red ginseng and its metabolite ginsenoside Rh3 in a chronic dermatitis model was investigated. Ginsenosides Rg5 and Rh3 suppressed swelling of oxazolone-induced mouse ear contact dermatitis. These ginsenosides also reduced mRNA expressions of cyclooxygenase-2, interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma. The inhibition of ginsenoside Rh3 was more potent than that of ginsenoside Rg5. These findings suggest that ginsenoside Rh3 metabolized from ginsenoside Rg5 may improve chronic dermatitis or psoriasis by the regulation of IL-1 beta and TNF-alpha produced by macrophage cells and of IFN-gamma produced by Th cells.

引用

页码：685 / 690

页数：6

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