Selectivity in the oligomerisation of G protein-coupled receptors

被引：8

作者：

Milligan, G ^{[1
]}

Lopez-Gimenez, J ^{[1
]}

Wilson, S ^{[1
]}

Carrillo, JJ ^{[1
]}

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Div Biochem & Mol Biol, Mol Pharmacol Grp, Glasgow G12 8QQ, Lanark, Scotland

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 03期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

G protein-coupled receptor; dimerisation; signal transduction;

D O I：

10.1016/j.semcdb.2003.12.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

G protein-coupled receptors can exist as dimers and/or higher order oligomers. Such quaternary structure appears central to their plasma membrane delivery and, potentially, to function. Recent evidence that these receptors can form hetero- as well as homo-dimers/oligomers has significant implications for pharmacology and pathophysiology. Knowledge of the basis and selectivity of GPCR hetero-dimerisation is thus vital. Current understanding of these areas is reviewed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

收藏

页码：263 / 268

页数：6

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