Use of transfer factor for the treatment of recurrent non-bacterial female cystitis (NBRC): A preliminary report.

被引:3
作者
DeVinci, C
Pizza, G
Cuzzocrea, D
Menniti, D
Aiello, E
Maver, P
Corrado, G
Romagnoli, P
Dragoni, E
LoConte, G
Riolo, U
Masi, M
Severini, G
Fornarola, V
Viza, D
机构
[1] S ORSOLA M MALPIGHI HOSP,DEPT PEDIAT,BOLOGNA,ITALY
[2] UNIV BOLOGNA,FAC MED,BOLOGNA,ITALY
[3] S MARIA CROCI HOSP,DIV UROL,RAVENNA,ITALY
[4] FAC MED ST PERES,CNRS,URA 1294,IMMUNOBIOL LAB,PARIS,FRANCE
关键词
cell-mediated immunity; cystitis; herpes virus; transfer factor;
D O I
10.1007/BF02628670
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Results of conventional treatment of female non-bacterial recurrent cystitis (NBRC) are discouraging. Most patients show an unexpected high incidence of vaginal candidiasis, while their cell mediated immunity to Herpes simplex viruses (HSV) and Candida antigens seems impaired, and it is known that the persistence of mucocutaneous chronic candidiasis is mainly due to a selective defect of CMI to Candida antigens. Twenty nine women suffering of NBRC, and in whom previous treatment with antibiotics and non-steroid antiinflammatory drugs was unsuccessful, underwent oral transfer factor (TF) therapy. TF specific to Candida and/or to HSV was administered bi-weekly for the first 2 weeks, and then once a week for the following 6 months. No side effects were observed during treatment. The total observation period of our cohort was 24379 days with 353 episodes of cystitis recorded and a cumulative relapse index (RI) of 43. The observation period during and after treatment was 13920 days with 108 relapses and a cumulative RI of 23 (P<0.0001). It, thus, seems that specific TF may be capable of controlling NBRC and alleviate the symptoms.
引用
收藏
页码:133 / 138
页数:6
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