Placental transfer of intravenous nicardipine and disposition into breast milk during the control of hypertension in women with pre-eclampsia

被引：7

作者：

Matsumura, Hideyoshi ^{[1
]}

Takagi, Kenjiro ^{[1
]}

Seki, Hiroyuki ^{[1
]}

Ono, Yoshihisa ^{[1
]}

Ichinose, Shunichiro ^{[1
]}

Masuko, Hiroko ^{[1
]}

Fukatsu, Mayumi ^{[1
]}

Miyashita, Aiji ^{[2
]}

Mera, Ayako ^{[2
]}

机构：

[1] Saitama Med Univ, Dept Obstet & Gynecol, Saitama Med Ctr, Kawagoe, Saitama 3508550, Japan

[2] Astellas Pharma Inc, Drug Discovery Res, Drug Metab Res Labs, Osaka, Japan

来源：

HYPERTENSION IN PREGNANCY | 2014年 / 33卷 / 01期

关键词：

Breast milk; fetus; neonate; nicardipine; placental transfer; PREGNANCY; PHARMACOKINETICS; MANAGEMENT; HYDROCHLORIDE; DISORDERS; DIAGNOSIS;

D O I：

10.3109/10641955.2013.846367

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To assess nicardipine safety for fetuses and neonates. Methods: Nicardipine was measured in maternal plasma (MP), umbilical cord arterial (UaP) and venous (UvP) plasma and breast milk (BrM) of 18 women with severe preeclampsia. Results: Nicardipine was infused for a mean 11.9 +/- 10.5 days before and 4.6 +/- 1.6 days after delivery. Nicardipine dose and MP concentration were linearly correlated, as were MP with UaP, UvP, and BrM concentrations. The BrM/MP ratio was 0.06 to 0.30. The mean relative infant dose was 0.082%. Conclusion: Nicardipine is safe for fetuses and neonates due to its low levels of placental transfer and disposition in BrM.

引用

页码：93 / 101

页数：9

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